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Updated: Mar 19, 2026

Exploring Biomolecular Interaction Between the Molecular Chaperone Hsp90 and Its Client Protein Kinase Cdc37 using Field-Effect Biosensing Technology
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Hsp90-Cdc37-Cdk4的原子结构显示,Hsp90捕获并稳定了一个未折叠的激酶

Kliment A Verba1, Ray Yu-Ruei Wang1, Akihiko Arakawa2

  • 1Howard Hughes Medical Institute (HHMI) and the Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158, USA.

Science (New York, N.Y.)
|June 25, 2016
PubMed
概括

热冲击蛋白90 (Hsp90) 和它的Cdc37稳定了像Cdk4这样的客户端激酶. 这项研究揭示了它们的结构,显示Hsp90和Cdc37捕获激酶在未折叠状态.

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