七种协同合成后反应导致金属-有机框架晶体内类似酶的复杂性
Alejandro M Fracaroli1,2,3, Peter Siman1,2, David A Nagib1
1Department of Chemistry, University of California , Berkeley, California 94720, United States.
Journal of the American Chemical Society
|June 28, 2016
概括
研究人员使用七种后合成反应在金属有机框架 (MOF) 中创建了复杂的酶类活性位点. 这一突破使MOF能够进行复杂的化学反应,
科学领域:
- 材料科学
- 超分子化学
- 化学工程
背景情况:
- 在金属有机框架 (MOF) 中设计类似酶的复杂性是具有挑战性的.
- 在不损害MOF结构的情况下,在MOF孔中实现多个合成后反应是困难的.
研究的目的:
- 为了证明在MOF中进行多次合成后反应的可行性.
- 在MOF毛孔中协同纳入三,以创建类似酶的活性位点.
- 研究所取得的复杂性对催化活性的影响.
主要方法:
- 使用多变量MOF,MTV-IRMOF-74-III,用于合成后的修改.
- 在MOF毛孔中进行了三的七次共价纳入反应.
- 在合反应中利用了原始氨基功能 (-CH2NHBoc) 与芳香氨基 (-NH2) 的较高反应性.
主要成果:
- 在MTV-IRMOF-74-III MOF中成功执行了七次合成后反应.
- 将H2N-Pro-Gly-Ala-CONHL和H2N-Cys-His-Asp-CONHL序列共同纳入MOF有机支架中.
- 在整个多步反应过程中保持MOF的多孔性和结晶性.
- 观察到MOFs中变化的反应性的初步证据,这表明它们具有类似酶的催化能力.
结论:
- 展示了多步骤的MOF功能化的强大方法.
- 在MOF中成功创建了空间和组成异质的酶模拟活性位点.
- 开发的MOF平台显示了以前需要酶的催化反应的潜力.
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