基底前脑向侧面的 habenula 投射调节攻击奖励
Sam A Golden1,2, Mitra Heshmati1,2, Meghan Flanigan1,2
1Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Nature
|July 1, 2016
概括
研究人员找到了一个关键的大脑回路, 基本前脑到侧面大脑 (BF-lHb) 路径, 调节侵略的奖励方面. 这种途径调节了激进行为的动机, 而不是它的启动.
科学领域:
- 神经科学
- 行为神经科学
- 攻击的神经生物学
背景情况:
- 适应不良的攻击性与神经精神疾病有关,通常涉及对社会刺激的失调大脑奖励系统.
- 虽然已知引发侵略的脑部区域,但控制侵略动机的神经机制仍然不清楚.
研究的目的:
- 调查神经回路调节激进行为的动机价值.
- 建立一个小鼠模型来测量男性之间的激进互动的奖励特性.
主要方法:
- 开发了一个有条件的位置偏好 (CPP) 范式,使用下属入侵者作为雄性小鼠的攻击性行为的社会奖励.
- 使用光遗传学 (halorhodopsin和通道rhodopsin) 来选择性地激活或静止GABAergic投射从基底前脑 (BF) 到侧面的 habenula (lHb).
- 测量了神经元发射和CPP/有条件的地方厌恶 (CPA) 的变化,以评估侵略性相互作用的价值.
主要成果:
- 参与攻击的雄性小鼠在与入侵者相关的环境中产生了CPP,而非攻击性小鼠则显示了CPA.
- 在攻击者中抑制GABAergic BF- lHb通路增加了lHb活性并取消了CPP.
- 在非攻击者中激活GABAergic BF- lHb通路降低了lHb活性并诱导了CPP,但没有影响攻击的启动.
结论:
- GABAergic BF-lHb电路双向控制男性之间的激进行为的激励价值 (奖励价值).
- 这种电路特别调节与侵略相关的"想要"或奖励处理,独立于"喜欢"或启动行为.
- 提供了对侵略奖励神经基础的新见解, 这对于理解相关的神经心理疾病很重要.
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