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Updated: Mar 18, 2026

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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Published on: February 20, 2018

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在GPCR中,G蛋白与激素结合口袋的合

Brian T DeVree, Jacob P Mahoney, Gisselle A Vélez-Ruiz

    Nature
    |July 1, 2016
    PubMed
    概括

    在G蛋白合时,G蛋白合受体 (GPCR) 稳定了封闭的构造,即使没有激动剂,也会影响连接体的结合. 这种G蛋白相互作用增强了许多GPCR的激素亲和力.

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