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Updated: Mar 18, 2026

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration
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通过MANF进行免疫调节,促进视网膜的组织修复和再生成功

Joana Neves1, Jie Zhu1, Pedro Sousa-Victor1

  • 1Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945-1400, USA.

Science (New York, N.Y.)
|July 2, 2016
PubMed
概括

科学家们发现,通过调节血小板衍生生成长因子 (PDGF) 等信号传递的免疫细胞可以增强组织的修复. 这种通过中脑星细胞衍生神经营养因子 (MANF) 的免疫调节,可以改善受损视网膜的再生疗法.

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Neurogenesis and Regeneration of Nervous Tissue01:15

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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