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相关概念视频

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

17.0K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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Immunological Memory01:23

Immunological Memory

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Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
17.7K
Mitochondrial Membranes01:45

Mitochondrial Membranes

17.6K
A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
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Mitochondrial Membranes01:45

Mitochondrial Membranes

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Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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T Cell Types and Functions01:24

T Cell Types and Functions

3.1K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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相关实验视频

Updated: Mar 18, 2026

Real-time Monitoring of Mitochondrial Respiration in Cytokine-differentiated Human Primary T Cells
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Real-time Monitoring of Mitochondrial Respiration in Cytokine-differentiated Human Primary T Cells

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在T细胞内存中的线粒体网络

Marc Liesa1, Orian S Shirihai1

  • 1Division of Endocrinology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.

Cell
|July 2, 2016
PubMed
概括
此摘要是机器生成的。

T淋巴细胞根据其功能而改变其能量需求,这构成了生物能量挑战. 巴克和其他人. 发现线粒体形状的变化与T细胞命运决定有关.

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Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells
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Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells

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Multicolor Flow Cytometry-based Quantification of Mitochondria and Lysosomes in T Cells
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Multicolor Flow Cytometry-based Quantification of Mitochondria and Lysosomes in T Cells

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相关实验视频

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Real-time Monitoring of Mitochondrial Respiration in Cytokine-differentiated Human Primary T Cells
06:55

Real-time Monitoring of Mitochondrial Respiration in Cytokine-differentiated Human Primary T Cells

Published on: October 19, 2021

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Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells
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Multicolor Flow Cytometry-based Quantification of Mitochondria and Lysosomes in T Cells
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科学领域:

  • 细胞生物学
  • 免疫学
  • 线粒体生物学

背景情况:

  • T淋巴细胞表现出显著的代谢可塑性,适应ATP需求和营养利用,以履行不同的功能作用,如T记忆和T效应细胞.
  • 这种新陈代谢适应对T细胞内的线粒体带来了相当大的生物能量挑战,影响了细胞重塑.
  • 了解这些生物能量转变对于理解T细胞的分化和功能至关重要.

研究的目的:

  • 研究线粒体动力学与T细胞命运决定之间的关系.
  • 探索生物能量挑战如何影响T细胞重塑和功能专业化.
  • 阐明线粒体形态在T细胞分化中的作用.

主要方法:

  • 在不同的功能需求下分析T淋巴细胞代谢状态.
  • 在不同T细胞子集中的线粒体形态评估.
  • 关联研究将线粒体形状变化与T细胞命运标记联系起来.

主要成果:

  • T淋巴细胞在ATP需求和营养利用方面表现出显著的变化.
  • 观察到线粒体形状的显著变化与不同的T细胞命运有关.
  • 线粒体重塑成为T细胞命运选择的关键因素.

结论:

  • 线粒体形状是T细胞命运决定的关键因素.
  • T细胞功能的生物能量需求需要线粒体适应.
  • 这项研究为线粒体动力学与免疫细胞分化之间的相互作用提供了新的见解.