2016 年 EMT
M Angela Nieto1, Ruby Yun-Ju Huang2, Rebecca A Jackson3
1Instituto de Neurociencias CSIC-UMH, Avda. Ramón y Cajal s/n, 03550 San Juan de Alicante, Spain.
Cell
|July 2, 2016
概括
细胞可塑性,包括上皮 - 介质过渡 (EMT),驱动胚胎发育和疾病. 了解EMT
科学领域:
- 细胞可塑性和发育生物学
- 癌症研究和病理学
- 分子和细胞生物学
背景情况:
- 在胚胎发育和疾病进展中,上皮-介质过渡 (EMT) 是至关重要的.
- 而不是一个简单的二进制开关.
- 在器官纤维化和瘤进展中.
研究的目的:
- 审查目前关于EMT细胞可塑性和异质性的理解.
- 突出 EMT 研究的最新发现和持续挑战.
- 讨论EMT对癌症和纤维化等人类疾病的影响.
主要方法:
- 关于EMT的文献综述和当前研究.
- 讨论关键概念:细胞可塑性,异质性和过渡状态.
- 分析EMT在发育,纤维化和癌症进展中的作用.
主要成果:
- 它代表着细胞状态的连续性, 而不是单一的转变.
- 它的中介状态是器官纤维化和瘤进展的关键驱动因素.
- 在转移殖民中EMT的作用需要仔细解释.
结论:
- 细胞的可塑性,特别是EMT,对于理解复杂疾病至关重要.
- 需要进一步的研究来解决悬而未决的问题,并克服EMT领域的挑战.
- 继续研究EMT的异质性和可塑性将推动疾病治疗策略.
相关概念视频
Methods of Documentation VII: EMR
1.5K
Electronic Medical Records (EMRs) primarily center around electronically documenting patients' health information within a single healthcare organization or practice. They contain essential clinical data related to a patient's medical history, diagnoses, medications, treatment plans, lab results, and other pertinent information relevant to the specific encounter or episode of care. EMRs are designed to streamline documentation and workflow processes within individual healthcare...
1.5K
Holter Monitor: 24-Hour Monitoring
3.9K
Holter monitoring is a continuous electrocardiography (ECG) recording that tracks the heart's electrical activity over an extended period, generally 24 to 48 hours. This noninvasive diagnostic tool detects irregular heart rhythms that may not be captured during a standard ECG performed in a clinical setting.DeviceThe Holter monitor is a portable, small device connected to several electrodes on the patient's chest. These electrodes detect the heart's electrical signals and transmit them to the...
3.9K
Cardiopulmonary Resuscitation V: Advanced Airway Management Techniques
748
Airway management is essential in emergency and surgical medicine, ensuring ventilation and oxygenation in patients who cannot maintain their own airway. Clinicians use a range of techniques and devices to secure the airway, depending on the patient’s condition and the clinical context. Key methods include endotracheal intubation, rapid sequence intubation (RSI), supraglottic airway devices, and advanced visualization aids. In cases where these approaches fail, surgical airway...
748
Applications of EMF Measurements
38
Electromotive force (EMF) measurements have a broad range of applications in various fields, including chemistry and physics. The electrochemical series, an arrangement of elements in order of their standard electrode potentials, can be determined through EMF measurements. Elements with lower standard potentials can reduce ions of elements with higher standard potentials.The standard cell potential, E°, allows for the calculation of the standard reaction Gibbs energy, ΔG°, and...
38
Current Trends in Nursing II
3.6K
Trends in nursing are multifactorial and associated with changes in society, within the nursing profession, and in other professions. Notably, telehealth and remote nursing contribute to successful healthcare delivery for numerous patients and help reduce stress for nurses due to nursing shortages. Nurses can reach patients, monitor their conditions, and interact with them using computers, audio, visual accessories, and telephones—for example, remote patient monitoring systems. Likewise,...
3.6K


