通过可生物降解聚合体的奥斯摩斯诱导形状转换形成明确的功能纳米管
Loai K E A Abdelmohsen1, David S Williams1, Jan Pille1
1Institute for Molecules and Materials, Radboud University , Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.
Journal of the American Chemical Society
|July 5, 2016
概括
研究人员从聚合物中制造出可生物降解的纳米管. 这些生物相容,高面比纳米颗粒可以装载药物,并与生物医学应用的蛋白质功能化.
科学领域:
- 生物材料科学
- 纳米技术
- 聚合物化学
背景情况:
- 聚合物是适应性纳米结构,具有可调节的特性,对生物医学应用至关重要.
- 由于形状依赖的功能,非球形聚合体具有兴趣,但仅限于不可降解的材料.
- 在纳米医学中研究形状效应需要可降解的非球形纳米结构.
研究的目的:
- 开发一种可生物降解的非球形聚合体的方法.
- 展示这些新型纳米结构在生物医学应用中的实用性.
- 建立一个高面积纳米粒子的新平台.
主要方法:
- 由聚乙烯基醇-b-聚乙烯-d,l-乳化物制成的球形聚合物的自发延长成纳米管.
- 使用透析来调节纳米管大小的透控制.
- 通过生物直角点击化学对纳米管表面进行功能化.
主要成果:
- 从可生物降解的聚合物中成功生成精确的纳米管.
- 通过透方法证明了纳米管的尺寸控制.
- 证实了将药物和功能性蛋白质加载到纳米管表面的能力.
结论:
- 创建了一个创新的平台来创建具有生物相容性,高面积的纳米粒子.
- 可生物降解的聚合物可以转化为尺寸可调的纳米管.
- 这些纳米管在纳米医学中提供了有前途的药物输送和蛋白质功能化系统.
相关概念视频
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