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缺乏TTC39B可以稳定LXR,减少动脉样硬化和脂肪肝

Joanne Hsieh1, Masahiro Koseki1,2, Matthew M Molusky1

  • 1Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York 10032, USA.

Nature
|July 8, 2016
PubMed
概括

甲基重复域蛋白39B (T39) 促进肝脏X受体 (LXR) 的降解. 通过保持LXR活性,抑制T39可以预防脂肪肝炎和动脉样硬化.

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