扩展蝶颜色视力的三向随机选择背后的分子逻辑
Michael Perry1, Michiyo Kinoshita2, Giuseppe Saldi3
1Department of Biology, New York University, New York, New York 10003, USA.
Nature
|July 8, 2016
概括
蝶使用一种新奇的遗传机制, 这允许更复杂的颜色比较和适应不同的环境.
科学领域:
- * 发育生物学
- *神经科学
- * 进化生物学
背景情况:
- * 蝶具有复杂的色彩视觉,依赖于不同单元眼睛 (ommatidia) 的多个Rhodopsin蛋白质.
- * Drosophila melanogaster 使用由转录因子控制的两种体类型,而蝶则表现出三种.
- * 了解蝶中三种类型的遗传基础是解释它们增强色彩感知能力的关键.
研究的目的:
- * 阐明了蝶中产生三种随机形类型的发育机制.
- * 调查转录因子在蝶视网膜发育中的作用.
- 了解这种机制如何促进色彩视觉的扩展和进化适应.
主要方法:
- * 对日本黄黄尾蝶 (Papilio xuthus) 和彩色蝶 (Vanessa cardui) 的体外发育进行比较分析.
- * 利用CRISPR/Cas9基因编辑来淘汰光受体细胞中的无脊柱基因.
- * 在野生类型和突变蝶中检查了Rhodopsin表达模式和体型分布.
主要成果:
- * 蝶具有两个R7类光受体,随着随机无脊柱表达决定蓝色或紫外线的敏感性.
- * 这种二进制决策,加上协调的Rhodopsin表达,产生了三种不同的ommatidial类型.
- * 无脊椎淘汰导致均的UV/UV体,证实它在产生体多样性的关键作用.
结论:
- 一个简单的两个二进制随机决定的遗传机制在蝶中产生了三种类型.
- * 这种策略可以部署额外的Rhodopsins (例如,红色敏感) 以扩展色彩视觉.
- * 这些发现表明产生发育多样性和进化新奇性的潜在通用机制.
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