可生物吸收的血管支架用于冠状动脉再血管
Dean J Kereiakes1, Yoshinobu Onuma2, Patrick W Serruys2
1From The Christ Hospital, Heart and Vascular Center, Lindner Research Center, Cincinnati, OH (D.J.K.); Thorax Centre, Erasmus MC, Rotterdam, The Netherlands (Y.O.); International Centre for Cardiovascular Health, Imperial College, London, UK (P.W.S.); and New York Presbyterian Hospital, Columbia University Medical Center, and the Cardiovascular Research Foundation, New York (G.W.S.). lindner@thechristhospital.com.
Circulation
|July 13, 2016
概括
可生物吸收的支架提供了金属支架的替代方案, 需要进一步的研究来评估与药物释放支架相比的长期安全性和有效性.
科学领域:
- 心血管医学
- 生物材料科学
背景情况:
- 金属药物释放支架 (DES) 具有很好的1年效果,但具有长期风险,如支架血栓和心肌梗塞.
- 永久性金属框架和DES中的聚合物与非常晚的不良事件有关.
- 可生物吸收的支架 (BRS) 旨在提供暂时的机械支持和药物输送,最终重新吸收以恢复血管功能.
研究的目的:
- 评估第一代生物吸收支架与当代金属药物释放支架相比的非劣势.
- 通过使血管恢复,评估可生物吸收支架的潜力,以改善非常晚的临床结果.
主要方法:
- 首代生物吸收支架与金属药物释放支架的比较.
- 评估整体1年以患者为导向和以设备为导向的结果.
- 对支架血栓的分析和与目标血管相关的心肌梗塞率.
主要成果:
- 第一代可生物吸收的支架在1年的结果中表现出与金属DES相比的非劣势.
- 在可生物吸收的支架中观察到更高的支架血栓形成率和目标血管心肌梗塞.
- 潜在的缓解策略包括改善患者/损伤选择,程序技术和设备开发.
结论:
- 可生物吸收的支架是金属DES的替代品,具有可比的短期成果.
- 长期安全性和有效性需要通过大规模随机试验进行进一步的研究.
- 优化设备设计和植入协议对于解决安全问题至关重要.
相关概念视频
The Blood-brain Barrier
47.4K
Overview
47.4K
Blood Flow
57.5K
Blood is pumped by the heart into the aorta, the largest artery in the body, and then into increasingly smaller arteries, arterioles, and capillaries. The velocity of blood flow decreases with increased cross-sectional blood vessel area. As blood returns to the heart through venules and veins, its velocity increases. The movement of blood is encouraged by smooth muscle in the vessel walls, the movement of skeletal muscle surrounding the vessels, and one-way valves that prevent backflow.
57.5K
Coronary Circulation
10.1K
The heart, an organ critical to survival, gets nourishment not from the blood it pumps but from a separate circulation system known as coronary circulation. This is the shortest circulation in the body and is responsible for supplying the heart with the nutrients it needs to function effectively.
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
10.1K
Overview of Blood Vessels
11.3K
The human cardiovascular system comprises five primary types of blood vessels: arteries, arterioles, veins, venules, and capillaries, each serving unique functions.
Arteries and Arterioles: Arteries are muscular and elastic vessels that primarily carry oxygenated blood from the heart to body tissues, except for the pulmonary artery, which carries deoxygenated blood. They have thick walls to withstand high pressure and contain a layer of muscle tissue, allowing them to expand or contract as...
Arteries and Arterioles: Arteries are muscular and elastic vessels that primarily carry oxygenated blood from the heart to body tissues, except for the pulmonary artery, which carries deoxygenated blood. They have thick walls to withstand high pressure and contain a layer of muscle tissue, allowing them to expand or contract as...
11.3K
Development of Blood Vessels
2.0K
The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
2.0K
Anatomy of Blood Vessels
4.5K
The vascular system, an integral part of the circulatory system, comprises various blood vessels that play crucial roles in maintaining the body's homeostasis. These blood vessels form a complex and efficient circulatory network. The three primary categories of blood vessels are the arteries, veins, and capillaries.
Arteries
Arteries circulate oxygenated blood from the heart, except the pulmonary artery, which transports deoxygenated blood to the lungs. Large arteries, such as the aorta,...
Arteries
Arteries circulate oxygenated blood from the heart, except the pulmonary artery, which transports deoxygenated blood to the lungs. Large arteries, such as the aorta,...
4.5K


