灵长类大脑发育的综合转录地图
Trygve E Bakken1, Jeremy A Miller1, Song-Lin Ding1
1Allen Institute for Brain Science, Seattle, Washington 98109, USA.
Nature
|July 14, 2016
概括
这项研究绘制了 rhesus 子的大脑发育图, 揭示了神经回路形成的基因表达模式. 研究结果将发育中的大脑中的特定基因表达与神经发育障碍联系起来.
科学领域:
- 神经科学
- 基因组学
- 发育生物学
背景情况:
- 了解人类大脑的发育是有限的, 尤其是灵长类动物.
- 非人类灵长类模型提供了对人类特异性发展过程的洞察.
研究的目的:
- 创建一个高分辨率的 rhesus子大脑发育的转录图谱.
- 在产前和产后发育期间调查基因表达模式.
- 确定发育基因表达与神经发育障碍之间的联系.
主要方法:
- 产前和产后 rhesus 子大脑的密集时间采样.
- 皮层和皮下区域的细分解剖学.
- 在发育中的脑组织中分析基因表达特征.
主要成果:
- 基因表达在出生前迅速发生变化,
- 皮质层和区域在出生后晚期达到成年人的分子形状.
- 患有自闭症和精神分裂症等疾病的候选风险基因在发育中的新皮质中表现出特定疾病的丰富性.
- 人类大脑的发育与子有相似之处,一些人类特异性的基因调节表明长期成熟.
结论:
- rhesus的转录图表为研究大脑发育提供了宝贵的资源.
- 发育基因表达模式与神经发育障碍的风险有关.
- 比较分析突出了灵长类大脑发育的保存和人类特异性方面.
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