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Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
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有效的反意义基因调节通过非化,聚乙烯糖醇刷

Xueguang Lu1, Fei Jia1, Xuyu Tan1

  • 1Department of Chemistry and Chemical Biology, Northeastern University , Boston, Massachusetts 02115, United States.

Journal of the American Chemical Society
|July 16, 2016
PubMed
概括

研究人员开发了一种新型非性聚合物聚乙烯糖醇,作为生物相容的转染载体. 这种方法增强了DNA稳定性和细胞吸收,没有观察到细胞毒性,为寡核酸治疗提供了有前途的解决方案.

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