较高的访问到访问低密度脂蛋白胆固醇变化与较低的认知能力,较低的脑血流和较大的白质超强载荷有关
Roelof A J Smit1, Stella Trompet1, Behnam Sabayan1
1From Department of Cardiology (R.A.J.S., S.T., J.W.J.), Section of Gerontology and Geriatrics, Department of Internal Medicine (R.A.J.S., S.T., B.S., A.J.M.d.C.), Department of Radiology (B.S., J.v.d.G., M.A.v.B.), Department of Clinical Epidemiology (S.l.C.), Department of Medical Statistics and Bioinformatics (S.l.C.), and Einthoven Laboratory for Experimental Vascular Medicine (J.W.J.), Leiden University Medical Center, Leiden, The Netherlands; and Interuniversity Cardiology Institute Netherlands, Utrecht, The Netherlands (J.W.J.).
低密度脂蛋白胆固醇 (LDL-C) 的高变化与认知功能和大脑健康状况的恶化有关. 这种关联无论是平均的LDL-C水平还是他类药物的使用,都会影响记忆,处理速度和脑成像标记.
科学领域:
- 神经科学
- 心血管医学
- 老年学
背景情况:
- 低密度脂蛋白胆固醇 (LDL-C) 的个体内变化预测心血管和脑血管事件.
- 之前的研究表明LDL-C的变化对血管健康的影响.
- 这种变异性对认知功能的延伸仍然未被探索.
研究的目的:
- 研究LDL-C可变性与认知功能之间的关联.
- 探索潜在的神经成像途径将LDL-C变化与认知衰退联系起来.
- 评估LDL-C的变化是否影响认知领域和大脑结构/功能.
主要方法:
- 这项研究分析了PROSPER试验中的4428名参与者.
- 在基线后的四次测量中,LDL- C的变化被测量为个体内标准偏差.
- 认知功能和神经成像结果 (大脑血流,白质高强度) 在LDL- C变异性方面进行了评估,以平均LDL- C和风险因素进行调整.
主要成果:
- 较高的LDL-C可变性与多个领域的认知能力下降相关,包括选择性注意力,处理速度和记忆力.
- 增加的LDL- C可变性与大脑血流减少和白质强度负荷增加有关.
- 这些关联独立于平均LDL- C水平和普拉瓦斯治疗.
结论:
- 访问到访问的LDL-C变化是认知衰退的独立预测因素.
- 增加的LDL- C可变性与神经成像的不良结果有关,包括脑血流减少和白质强度增加.
- 这些发现强调了LDL-C稳定对维持认知健康和大脑完整性的重要性.
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