相关实验视频

Updated: Mar 17, 2026

Combined DNA-RNA Fluorescent In situ Hybridization FISH to Study X Chromosome Inactivation in Differentiated Female Mouse Embryonic Stem Cells
15:54

Combined DNA-RNA Fluorescent In situ Hybridization FISH to Study X Chromosome Inactivation in Differentiated Female Mouse Embryonic Stem Cells

Published on: June 14, 2014

28.6K

在小鼠中不活跃的X染色体的结构组织

Luca Giorgetti, Bryan R Lajoie, Ava C Carter

    Nature
    |July 21, 2016
    PubMed
    概括

    X染色体不活化 (XCI) 重组了不活跃的X染色体. Xist RNA 和 DXZ4 边界对 Xi 结构至关重要,形成大域并减少 DNA 的可访问性,除了保留结构的逃生基因之外.

    更多相关视频

    A Non-random Mouse Model for Pharmacological Reactivation of Mecp2 on the Inactive X Chromosome08:27

    A Non-random Mouse Model for Pharmacological Reactivation of Mecp2 on the Inactive X Chromosome

    Published on: May 22, 2019

    6.9K
    Pooled shRNA Screen for Reactivation of MeCP2 on the Inactive X Chromosome11:15

    Pooled shRNA Screen for Reactivation of MeCP2 on the Inactive X Chromosome

    Published on: March 2, 2018

    7.7K

    相关概念视频

    Inheritance of Chromatin Structures03:17

    Inheritance of Chromatin Structures

    Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
    7.8K
    X-Inactivation01:58

    X-Inactivation

    The human X chromosome contains over ten times the number of genes as in the Y chromosome. Since males have only one X chromosome, and females have two, one might expect females to produce twice as many of the proteins, with undesirable results.
    43.0K
    X-inactivation01:58

    X-inactivation

    6.8K
    Euchromatin01:01

    Euchromatin

    The extent of chromatin compaction can be studied by staining chromatin using specific DNA binding dyes. Under the microscope, the dense-compacted regions take up more dye, appearing darker, while the less-compact areas take up less dye and appear lighter. Based on the compaction level, chromatins are classified into two primary forms – euchromatin and heterochromatin.
    Euchromatin is the less dense region of the chromatin and stains lighter. Euchromatin contains histone H3 extensively...
    9.2K
    Heterochromatin02:38

    Heterochromatin

    The extent of chromatin compaction can be studied by staining chromatin using specific DNA binding dyes. Under the microscope, the dense-compacted regions that take up more dye are called heterochromatin. Heterochromatin is further classified into two forms – constitutive heterochromatin and facultative heterochromatin.
    Constitutive heterochromatin: It is a highly compact region of chromatin that is mostly concentrated in the centromere and telomere. Unlike euchromatin, the amino acid at...
    18.9K
    Dosage Compensation02:50

    Dosage Compensation

    In animals, gender is determined by the number and type of sex chromosome. For example, human females have two X chromosomes, and males have one X and one Y chromosome, whereas C.elegans with one X chromosome is a male, and the one with two X chromosomes is a hermaphrodite.
    In addition to sexual development, the X chromosome has genes involved in autosomal functions such as brain development and the immune system. Therefore, males and females with  distinct numbers of X chromosomes will...
    7.7K