肠道微生物群与人类的共同物种化
Andrew H Moeller1, Alejandro Caro-Quintero2, Deus Mjungu3
1Department of Integrative Biology, 2506 Speedway A5000, University of Texas at Austin, Austin, TX 78712, USA. Miller Institute for Basic Research in Science, 2536 Channing Way, University of California, Berkeley, CA 94720, USA.
概括
人类的肠道细菌与我们的灵长类祖先一起进化. 这项研究揭示了古老的细菌系与人类和非洲人猿共存1500万年,
科学领域:
- 微生物生态学
- 进化生物学
- 人类微生物组研究
背景情况:
- 人类肠道微生物组的进化历史和起源在很大程度上是未知的.
- 了解肠道细菌及其宿主的共同进化对于理解宿主-微生物相互作用至关重要.
研究的目的:
- 研究人类肠道中主要的细菌系的进化起源.
- 确定肠道细菌是否与它们的原始宿主一起形成.
主要方法:
- 分析人类,黑猩猩,黑猩猩和大猩猩的肠道微生物的菌株水平多样性.
- 对细菌和宿主进化史进行基因分析.
- 细菌类和人类系的分离时间估计.
主要成果:
- 多个肠道细菌系,包括Bacteroidaceae和Bifidobacteriaceae,显示出与人类的共同物种.
- 这些细菌系数已经在宿主系中维持了数百万年.
- 细菌的分歧时间与人类的进化分歧时间一致,表明同步的多样化.
结论:
- 人类的主要肠道细菌起源于与人类和非洲子一起形成的古代共生生物.
- 人类的肠道微生物组与灵长类的进化有着深厚的进化历史.
- 在形成人类肠道微生物组的过程中,共同物种发挥了重要作用.
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