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相关概念视频

Imprinting01:22

Imprinting

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Behavioral imprinting is observed in some newborn animals and occurs when they develop strong and specific attachments to another animal (usually a parent) following brief, early-life exposures. Offspring imprint onto parents within a brief period after birth or hatching; this time window is called the critical period. Once imprinting occurs, the bond established between the parents and their offspring is usually long-lasting.
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Higher Mental Functions of Brain: Learning and Memory01:26

Higher Mental Functions of Brain: Learning and Memory

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Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or...
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相关实验视频

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Author Spotlight: Advancing Large-Scale Neural Dynamics Through HD-MEA Technology
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印记和回忆皮层组件

Luis Carrillo-Reid1, Weijian Yang2, Yuki Bando2

  • 1NeuroTechnology Center, Department of Biological Sciences, Columbia University, New York, NY 10027, USA. lc2998@columbia.edu.

Science (New York, N.Y.)
|August 13, 2016
PubMed
概括

研究人员使用双光子光遗传学在小鼠视觉皮层中印制了新的神经元组合. 这些工程神经元组自发复发,可以被召回,证明电路可塑性.

科学领域:

  • 神经科学
  • 系统神经科学
  • 皮层电路

背景情况:

  • 神经元组合,协同活动的神经元组,对于皮质电路功能至关重要.
  • 赫比可塑性,加强协作神经元之间的突触,是组合形成的一个建议机制.

研究的目的:

  • 研究双光子光遗传学在视觉皮层内设计和印制特定的神经元组合的潜力.
  • 为了确定印记组合是否表现出自发的复发和随时间的稳定性.
  • 评估印记对先前存在的神经网络的影响.

主要方法:

  • 使用双光子光遗传学在清醒的小鼠中重复激活特定的神经元群.
  • 专注于视觉皮层中的神经元组合.
  • 使用单细胞刺激来测试印记组合的回忆.

主要成果:

  • 在激活后自发复发的成功印记的神经元组合.
  • 证明印记不会破坏已经存在的神经元组合.
  • 通过单细胞刺激, 印记组合可以被召回, 并连续几天保持协同活性.
  • 证实了持续的电路重构成功能神经元组合.

结论:

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  • 两光子光遗传学可以在视觉皮层中创建稳定的人工神经元组合.
  • 印记的神经元组合表现出自然组合的特性,包括自发的复发和回忆.
  • 这种技术为功能研究或治疗应用提供了精确,持续的皮质电路修改方法.