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Updated: Mar 16, 2026

Method for Measuring the Activity of Deubiquitinating Enzymes in Cell Lines and Tissue Samples
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杜比基因酶OTULIN是炎症和自身免疫的重要负调节剂

Rune Busk Damgaard1, Jennifer A Walker1, Paola Marco-Casanova1

  • 1Medical Research Council Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK.

Cell
|August 16, 2016
PubMed
概括

通过调节与M1结合的ubiquitin链,杜比基因酶OTULIN可以防止危险的炎症. 虽然OTULIN缺乏导致严重的自身炎症综合征 (ORAS),但抗TNF疗法可以治疗患者和小鼠.

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