相关实验视频
Updated: Sep 29, 2026
07:29
Programmed Electrical Stimulation in Mice
Published on: May 26, 2010
在心房节重入性心动减速症中,可刺激的间隙. 用心室外刺激和药理干预进行表征
C D Schuger1, R T Steinman, M H Lehmann
1Electrophysiology Laboratory, Wayne State University, Detroit, Michigan.
Circulation
|August 1, 1989
概括
这项研究研究了心房节点复发性心动减速 (AVNRT) 的可刺激差距,发现药物干预可以揭示这一差距,支持AVNRT中的微复发性机制.
科学领域:
- 电子生理学 电子生理学
- 心脏病学 心脏病学
背景情况:
- 心房节回入性心力衰竭 (AVNRT) 是一种常见的超心室性心力衰竭.
- 了解AVNRT的电生理基质对于有效管理至关重要.
研究的目的:
- 为了描述在AVNRT期间可激发的差距.
- 为了阐明这种微型进入性心律失常的电生理基质.
- 评估维拉帕米尔对兴奋区间的影响.
主要方法:
- 在11名患者的AVNRT期间输送心室外刺激 (V2).
- 测量心房前兴奋和心动节拍恢复.
- 用维拉帕米尔来评估其对兴奋区间的影响.
主要成果:
- 在基线时,有45%的患者存在刺激性缺口.
- 维拉帕米尔扩大了预兴奋区,并增加了最大心房预兴奋.
- AVNRT被V2始终重置,在verapamil后的反应模式增加.
结论:
- 相当数量的AVNRT患者具有可兴奋性缺口,可通过维拉帕米尔增强.
- 越来越多的重置响应模式支持AVNRT.中的回入机制.
- 完全可激发的空隙的存在表明一个微型进入电路涉及一个解剖障碍物.
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