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瘤缺氧通过降低TET活性导致DNA高甲基化

Bernard Thienpont1,2, Jessica Steinbacher3, Hui Zhao1,2

  • 1Vesalius Research Center, VIB, Leuven, Belgium.

Nature
|August 18, 2016
PubMed
概括

瘤缺氧或低氧降低了十-十一转位酶 (TET) 的活性,导致DNA高甲基化. 这种缺氧驱动的表观遗传变化促进了癌细胞的生长,可能占所有高甲基化事件的一半.

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