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相关概念视频

Convergent Evolution01:54

Convergent Evolution

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Evolution shapes the features of organisms over time, ensuring that they are suited for the environments in which they live. Sometimes, selection pressure leads to the rise of similar but unrelated adaptations in organisms with no recent common ancestors, a process known as convergent evolution.
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Lampbrush Chromosomes01:51

Lampbrush Chromosomes

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In 1882, Flemming observed lampbrush chromosomes (LBC) in salamander eggs. Later in 1892, Rückert observed LBCs in shark egg cells and coined the term "lampbrush chromosomes" because they looked like brushes used to clean kerosene lamps.
LBCs are made up of two pairs of conjugating homologous chromatids. Each chromatid consists of alternatively positioned regions of condensed-inactive chromatin and loosely placed-active side loops, which can be contracted and extended. The loops...
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Gastrulation01:56

Gastrulation

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Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...
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Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy
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数字和光有着共同的发展历史

Tetsuya Nakamura1, Andrew R Gehrke1, Justin Lemberg1

  • 1Department of Organismal Biology and Anatomy, University of Chicago, Chicago, Illinois 60637, USA.

Nature
|August 18, 2016
PubMed
概括

四足动物的手指是从鱼翅射线进化而来的 斑马鱼的Hox13基因操纵揭示了光细胞可以形成数字前体,这表明了直接的进化联系.

科学领域:

  • 进化发育生物学
  • 比较解剖学
  • 遗传学

背景情况:

  • 四足动物从鱼进化是脊椎动物进化的关键问题.
  • 翅膀和四肢之间的结构和发育差异阻碍了数字起源的理解.
  • 关于翅膀骨发育的细胞和分子机制的数据有限.

研究的目的:

  • 研究5'霍克斯基因和增强剂在斑马鱼翅膀发育中的作用.
  • 为了确定鱼翅和四足动物的细胞和遗传联系.
  • 探索四足动物的进化起源.

主要方法:

  • 在斑马鱼中进行CRISPR/Cas9基因编辑.
  • 为了追踪细胞系的命运映射.
  • 假基因和增强剂的功能分析.

主要成果:

  • Hoxa13增强剂的活性标志着形成折元素的细胞,包括皮肤射线骨质细胞.
  • 霍克斯13淘汰赛斑马鱼表现出减少的光线和增加的内分体远端光线.
  • 证明了翅膀光线和四足动物的手指之间的细胞和遗传联系.

结论:

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  • 四足动物的手指可能起源于鱼翅的远端细胞命运的转变.
  • 霍克斯13基因在的远端骨架模式中起着至关重要的作用,类似于四足动物的四肢发育.
  • 这项研究提供了关于翅膀到四肢转换的新洞察力.