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Updated: May 8, 2026

Synthesis of Protein Bioconjugates via Cysteine-maleimide Chemistry
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Published on: July 20, 2016

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过渡无金属酸盐选择性蛋白质生物结合

Yohei Seki1, Takashi Ishiyama1, Daisuke Sasaki1,2

  • 1Graduate School of Pharmaceutical Sciences, The University of Tokyo , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Journal of the American Chemical Society
|August 19, 2016
PubMed
概括

这项研究引入了一种新的无金属方法,用于使用有机基的选择性蛋白质修饰. 这种方法可以在温和条件下进行精确的生物结合,从而增强蛋白质的功能,从而有潜在的治疗用途.

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相关概念视频

Conjugated Proteins02:50

Conjugated Proteins

Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
Conjugated Proteins02:50

Conjugated Proteins

Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...