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Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

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Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
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Assessment of the Cardiovascular System III: Palpation01:27

Assessment of the Cardiovascular System III: Palpation

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Palpation involves feeling the body to evaluate texture, size, consistency, and tenderness for assessing cardiovascular health. The following steps are organized in a head-to-toe order:
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above...
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Peripheral Artery Disease IV: Nursing Management01:26

Peripheral Artery Disease IV: Nursing Management

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 The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
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Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

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Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
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Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

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Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
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Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
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与慢性血管并发症相关的状细胞疾病中的动脉硬性损伤:非洲多国CADRE研究

Brigitte Ranque1, Aymeric Menet2, Pierre Boutouyrie2

  • 1From Internal Medicine Unit, Hôpital Européen Georges Pompidou, Assistance Publique des Hôpitaux de Paris, France (B.R.); UMR_S970, Inserm, Paris, France (B.R., P.B., S.L.J., X.J.); Faculté de médecine, Université Paris Descartes, France (B.R., P.B., X.J.); Cardiology Unit, groupement des hôpitaux de l'université catholique de Lille, université catholique de Lille, France (A.M.); Physiology Unit, Hôpital Européen Georges Pompidou, Assistance Publique des Hôpitaux de Paris, France (P.B.); Cardiology Unit, CHU de Fann, Dakar, Senegal (I.B.D., G.L.); Cardiology Unit, Hôpital Général, Yaoundé, Cameroon (S.K.); Cardiology Unit, Centre Gynéco-obstétrique, Bamako, Mali (M.D., C.O.D.); Institut de cardiologie, Abidjan, Ivory Coast (R.N'G.); Centre de recherche et Lutte contre la Drépanocytose, Bamako, Mali (D.D., Y.T.); Centre National de Transfusion Sanguine, Dakar, Senegal (S.D., B.F.F., M.S.); Pediatrics Unit, Centre Hopital Albert Royer, CHU de Fann, Dakar, Senegal (I.D., I.D.-L.); Hematology Unit, CHU de Yopougon, Abidjan, Ivory Coast (I.S., A.T., B.K., I.K.); Fondation Mère Enfant Chantal Biya, Yaoundé, Cameroon (D.C.); Pediatrics Unit, Centre Hospitalier d'Essos, Yaoundé, Cameroon (G.W.); CIRMF, Libreville, Gabon (J.P.G., C.A.); Internal Medicine Department, Hôpital Avicenne, Assistance Publique des Hôpitaux de Paris, France (S.L.J.); and Cardiology Department, Hôpital Européen Georges Pompidou, Assistance Publique des Hôpitaux de Paris France (X.J.). brigitte.ranque@egp.aphp.fr.

Circulation
|September 2, 2016
PubMed
概括
此摘要是机器生成的。

与对照组相比,状细胞病患者的动脉硬度,脉冲波速率 (PWV) 和增强指数 (AI) 都发生了变化. 这些变化与SCD并发症相关,表明预后值.

关键词:
没有血贫血,状细胞血液压力脉冲波分析血管疾病

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科学领域:

  • 心血管医学
  • 血液学
  • 血管生物学

背景情况:

  • 状细胞病 (SCD) 是一种导致慢性血管病变和多器官损伤的遗传性血液疾病.
  • 动脉硬是心血管健康的关键指标,也是血管并发症的预测因素.

研究的目的:

  • 评估SCD患者的动脉硬性.
  • 研究动脉硬与SCD相关的血管并发症之间的关联.

主要方法:

  • 在CADRE研究中,从五个非洲国家的SCD患者和对照人群进行了前性招募.
  • 测量了带脉冲波速率 (cf-PWV) 和增强指数 (AI).
  • 多变量回归分析探讨了与临床结果的相关性和关联性.

主要成果:

  • 在SCD患者中,平均cf-PWV低于对照组 (P< 0. 0001).
  • 在SCD患者中,AI随着年龄的增长而加快,在成人SCD患者中更高.
  • cf-PWV和AI与年龄,性别,血压,血红蛋白水平和国家有关.
  • cf-PWV和AI都独立地与膜过率和骨髓缩有关.
  • 艾滋病与中风,肺高血压和食欲不良有关;cf-PWV与微型白血病有关.

结论:

  • 在SCD患者中,脉冲波速度和增强指数发生显著变化.
  • 这些血管变化与临床因素和SCD并发症有关.
  • PWV和AI可能对SCD血管并发症具有预后价值,需要进一步评估.