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Updated: Mar 15, 2026

A Macrophage Reporter Cell Assay to Examine Toll-Like Receptor-Mediated NF-kB/AP-1 Signaling on Adsorbed Protein Layers on Polymeric Surfaces
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A Macrophage Reporter Cell Assay to Examine Toll-Like Receptor-Mediated NF-kB/AP-1 Signaling on Adsorbed Protein Layers on Polymeric Surfaces

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死细胞传感器Clec4e通过激活未折叠的蛋白质反应促进了前性巨类型

Marc Clément1, Gemma Basatemur1, Leanne Masters1

  • 1From Division of Cardiovascular Medicine, University of Cambridge, Cambridge, UK (M.C., G.B., L.M., L.B., J.G., Z.M.); Institut National de la Santé et de la Recherche Médicale, Paris Cardiovascular Research Center, Paris, France (P.B., Z.M.); Iwawaki Laboratory, Advanced Scientific Research Leaders Development Unit, Gunma University, Maebashi, Gunma, Japan (T.I.); Department of Preclinical Imaging and Radiopharmacy, Werner Siemens Imaging Center and Department of Dermatology (M.K.), Eberhard Karls University, Tübingen, Germany; and Division of Molecular Immunology, Medical Institute of Bioregulation, Kyushu University, Kyushu, Japan (S.Y.).

Circulation
|September 3, 2016
PubMed
概括

死亡细胞激活C型莱克受体4e (Clec4e) 会导致动脉样硬化,因为它会损害胆固醇的流失并促进炎症. 针对Clec4e信号可能为心血管疾病提供新的治疗策略.

关键词:
动脉样硬化细胞增殖炎症的发生死亡

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