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甲状腺功能和心脏突然死亡:基于人口的前性队列研究

Layal Chaker1, Marten E van den Berg1, Maartje N Niemeijer1

  • 1From Rotterdam Thyroid Center (L.C., R.P.P.), Department of Internal Medicine (L.C., B.H.C.S., R.P.P.), and Department of Epidemiology (L.C., M.E.v.d.B., M.N.N., O.H.F., A.D., A.H., M.E., B.H.C.S., R.P.P.), Erasmus University Medical Center; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA (A.H.); Departments of Medical Informatics (P.R.R.) and Cardiology (J.W.D.), Erasmus University Medical Center, Rotterdam, The Netherlands; and Inspectorate of Health Care, Utrecht, The Netherlands (B.H.C.S.).

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|September 8, 2016
PubMed
概括

即使在正常范围内,较高的自由甲状腺素 (FT4) 水平也与心脏突然死亡 (SCD) 的风险增加有关. 这一发现突显了FT4作为一般人群中SCD的潜在预测因素.

关键词:
死亡死亡,突然,心脏病流行病学甲状腺

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科学领域:

  • 内分泌学
  • 心脏病学
  • 流行病学

背景情况:

  • 甲状腺功能与心血管疾病有关.
  • 之前没有研究过甲状腺功能是突然心脏死亡 (SCD) 的风险因素.

研究的目的:

  • 评估甲状腺功能与突发心脏病死亡 (SCD) 风险之间的关系.

主要方法:

  • 包括10318名年龄≥45岁的参与者在内的前性队列研究 (鹿特丹研究).
  • 测量甲状腺刺激激素和自由甲状腺素 (FT4) 的水平.
  • 使用Cox比例风险模型和竞争风险模型来分析SCD风险,调整心血管风险因素.

主要成果:

  • 更高的FT4水平与增加的SCD风险有关 (HR为2. 28每1 ng/ dL的FT4),即使在正常甲状腺功能范围内.
  • 在FT4水平上升的参与者中,SCD的绝对10年风险从1%增加到4%.
  • 敏感性分析证实了这些发现的可靠性.

结论:

  • FT4水平升高与心脏突然死亡 (SCD) 的风险增加有关.
  • 这种关联即使在甲状腺功能正常的个体中也存在,这表明FT4可能是SCD的独立风险因素.