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在日常记忆中进行多巴胺强化
Tomonori Takeuchi1, Adrian J Duszkiewicz1, Alex Sonneborn2
1Centre for Cognitive and Neural Systems, Edinburgh Neuroscience, The University of Edinburgh, 1 George Square, Edinburgh EH8 9JZ, UK.
Nature
|September 8, 2016
概括
新鲜事物可以提高记忆力. 研究人员发现神经元在部, 而不是腹部部区域, 调解这种多巴胺依赖的效果, 这表明一种新的记忆增强途径.
科学领域:
- 神经科学
- 记忆研究
- 神经生物学
背景情况:
- 在人类和动物的编码前不久或之后,新奇性增强了情节性记忆.
- 这种多巴胺依赖的新奇效应以前仅归因于腹膜区域的氨酸酶表达 (TH+) 神经元.
研究的目的:
- 识别与新奇相关的多巴胺依赖性记忆增强中介的特定神经元.
- 调查神经元在与新奇相关的记忆增强中的作用.
主要方法:
- 在小鼠中使用日常记忆任务.
- 记录了神经元对环境新鲜事物的敏感性.
- 将LCTH+神经元和腹膜区域TH+神经元与海马进行比较.
- 使用光遗传激活LCTH+神经元.
- 没有激活腹膜区域.
- 在海马D1/D5受体阻塞和上腺受体阻塞.
主要成果:
- 神经元在部 (LC) 的激发对环境的新奇性非常敏感.
- 与腹膜区域TH+神经元相比,LCTH+神经元向海马体发射的范围更大.
- 对LCTH+神经元的光遗传激活复制了新奇感应的记忆增强.
- 腹膜区域的失活没有影响与新奇相关的记忆增强.
- 通过海马D1/ D5受体阻塞阻断了LC TH+光激活对记忆和突触增强的影响,而不是上腺受体阻断.
结论:
- 脑部TH+神经元,而不是腹部的TH+神经元, 介导编码后的记忆增强.
- 这种增强是多巴胺依赖的,通过海马D1/D5受体起作用.
- LCTH+神经元可能在海马中共释放多巴胺以促进记忆.
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