一种复杂的六环菌代谢物
Emily Mevers1, Josep Saurí2, Yizhou Liu2
1Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School , 240 Longwood Avenue, Boston, Massachusetts 02115, United States.
Journal of the American Chemical Society
|September 10, 2016
概括
研究人员发现了一种复杂的真菌代谢物, 它的产生是由细菌分子触发的,这表明对氧化应激的反应,并提供了对微生物化学生态的见解.
科学领域:
- * 微生物化学和化学生态学
- * 自然产品的发现和生物合成.
- * 菌类和细菌的相互作用
背景情况:
- * 微生物利用小分子来感知环境并作出反应.
- 了解这些分子对于化学,生物学和医学至关重要.
- * 研究重点是虫相关的行为细菌和病原菌之间的分子交换.
研究的目的:
- * 识别和描述涉及微生物相互作用的新型真菌代谢物.
- * 阐明同二素A的结构和形成途径.
- * 研究细菌代谢物在调节真菌化合物产生中的作用.
主要方法:
- 使用NMR光谱分离和阐明同素A的结构.
- * 化学结构分析,包括立体化学和多基骨架.
- * 拟议的非酶反应级联对荷莫迪米瑞辛A的形成.
- * 对巴菲洛米辛C1对真菌代谢物产生影响的研究.
主要成果:
- * 发现了一种新型的六环多基菌代谢物 - - homodimericin A.
- * 荷莫迪米瑞辛A具有具有挑战性的C20核与8个连续的立体碳.
- * 尽管代谢物具有复杂的立体化学成分,但它是作为一种血混合物产生的.
- * 细菌代谢物Bafilomycin C1强烈上调了荷莫迪美里辛A的产生.
结论:
- * 荷莫迪米瑞辛A是一种独特的真菌代谢物,产生于细菌信号的反应.
- * 一种可信的非酶途径解释了从阿基拉单体中形成的荷莫迪米瑞辛A.
- * 形成机制,六电子氧化,可能代表微生物对氧化应激的反应.
- 这些发现有助于我们更好地了解微生物化学生态和自然产品的生物合成.
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