让你的大脑吃一些好吃的食物
1Nomis Center for Immunobiology and Microbial Pathogenesis, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Cell
|September 10, 2016
概括
疾病导致厌食症, 改变细胞应激的代谢需求. 这对细菌和病毒感染的耐受性有不同的影响,优化宿主防御策略.
科学领域:
- 免疫学
- 代谢途径
- 宿主-病原体相互作用
背景情况:
- 感染期间宿主防御策略通常涉及养行为变化.
- 重新优先考虑养动机的目的是优化宿主对病原体的反应.
研究的目的:
- 研究疾病诱导的厌食症如何影响细胞应激适应的代谢需求.
- 确定厌食症在细菌和病毒感染期间对疾病耐受性的差异影响.
主要方法:
- 在感染期间分析与厌食症相关的代谢变化.
- 在厌食症条件下对宿主耐受性和病毒病原体的比较评估.
主要成果:
- 疾病引起的厌食症对细胞应激反应的代谢需求有所不同.
- 厌食症对疾病耐受性产生相反的影响,这取决于感染是细菌还是病毒.
结论:
- 疾病期间的食行为变化有明显的代谢后果.
- 了解这些代谢变化对于开发有针对性的疗法来提高对不同类型感染的耐受性至关重要.
相关概念视频
01:20Special Features of Adaptive Immunity
4.0K
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
4.0K
01:40Cell-mediated Immune Responses
85.7K
Overview
85.7K
01:24Tissue Transplantation
1.2K
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
1.2K
01:20Desensitization and Tachyphylaxis
3.3K
Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
3.3K
01:16Transduction
2.4K
Among the three main modes of HGT—transformation, conjugation, and transduction—transduction is unique in that it is mediated by bacteriophages, or bacterial viruses.Transduction occurs in two ways. Generalized transduction occurs during the lytic cycle of a bacteriophage infection. In this process, bacteriophages infect bacterial cells, replicate within them, and ultimately cause cell lysis, releasing newly assembled virions. Occasionally, random fragments of the bacterial genome...
2.4K
01:16Drug toxicity: Idiosyncratic Reactions
114
Idiosyncratic drug reactions represent abnormal chemical responses that vary significantly among individuals, ranging from extreme sensitivity to low doses to insensitivity to high doses. These reactions often occur due to the drug's covalent binding with serum proteins, forming a foreign hapten that triggers an immunotoxicological response. The variability in drug reactions has a strong pharmacogenetic foundation, with genetic differences crucial in how individuals metabolize drugs. For...
114