酒酵母的化和分化
Brigida Gallone1, Jan Steensels2, Troels Prahl3
1Laboratory for Genetics and Genomics, Centre of Microbial and Plant Genetics (CMPG), KU Leuven, Kasteelpark Arenberg 22, 3001 Leuven, Belgium; Laboratory for Systems Biology, VIB, Bio-Incubator, Gaston Geenslaan 1, 3001 Leuven, Belgium; Department of Plant Systems Biology, VIB, 9052 Gent, Belgium; Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Gent, Belgium.
Cell
|September 10, 2016
概括
人类的选择塑造了工业Saccharomyces cerevisiae酵母,创造了优化食品生产的独特血统. 这些化酵母表现出特殊的工业特征, 但与它们的野生祖先不同,
科学领域:
- 微生物学
- 进化生物学
- 基因组学
背景情况:
- 像Saccharomyces cerevisiae这样的食物微生物的化比植物和动物的化要少.
- 工业酵母菌株对于食品和饮料生产至关重要, 但它们的起源和进化途径尚不清楚.
研究的目的:
- 研究工业Saccharomyces cerevisiae菌株的化历史和进化差异.
- 识别由人类选择驱动的工业酵母的遗传和表型适应.
主要方法:
- 157个工业Saccharomyces cerevisiae菌株的基因组测序和表型.
- 对工业菌株与野生酵母菌种群进行比较分析.
- 分析特定行业的特征,如应力耐受性和风味生产.
主要成果:
- 工业酵母形成了五种不同的亚系,从遗传和表型上与野生菌株分开.
- 强烈的,行业特定的选择特征的证据,如压力耐受性和糖利用.
- 与自然生存有关的表型的衰变,特别是酒酵母的性循环.
- 确定各种工业品种的几个祖先来源.
结论:
- 工业性Saccharomyces cerevisiae酵母经历了重要的化和人类选择,导致了专门的菌株.
- 进化历史揭示了复杂的化模式和局部分歧,导致不同的亚系.
- 这些发现为酵母进化提供了洞察力,
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