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Yeast As a Chassis for Developing Functional Assays to Study Human P53
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通过乙化调节的p53和SET之间的相互作用显示出广泛的调节模式

Donglai Wang1, Ning Kon1, Gorka Lasso2

  • 1Institute for Cancer Genetics, Department of Pathology and Cell Biology, Herbert Irving Comprehensive Cancer Center, College of Physicians & Surgeons, Columbia University, 1130 Nicholas Ave, New York, NY 10032, USA.

Nature
|September 15, 2016
PubMed
概括

瘤蛋白SET蛋白与未乙化p53结合,抑制其活性. 压力诱导的p53CTD乙化破坏了这种结合,激活了p53并导致瘤回归,揭示了新的调节机制.

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