一个皮质电路的性二态氧化素依赖的焦虑行为
Kun Li1, Miho Nakajima1, Ines Ibañez-Tallon1
1Laboratory of Molecular Biology, Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
Cell
|September 20, 2016
概括
催产素受体内神经元 (OxtrINs) 通过表达皮质激素释放激素结合蛋白 (CRHBP),一种焦虑解消因子来调节雄性小鼠的焦虑. 这揭示了两性社会和情感行为的分子机制.
科学领域:
- 神经科学
- 行为内分泌学
- 分子精神病学
背景情况:
- 人类的社会和情绪障碍表现出基于性别的流行差异.
- 之前已经证明氧化素受体内神经元 (OxtrINs) 能调节女性的社会性行为.
研究的目的:
- 研究OxtrINs在男性焦虑相关行为中的作用.
- 在社会和情绪调节中确定奥克斯特林功能的分子机制.
- 通过催产素和压力路径探索神经电路调节的性别特异性.
主要方法:
- 使用雄性小鼠模型研究与焦虑相关的行为.
- 研究了OxtrINs中的皮质释放激素结合蛋白 (CRHBP) 的表达.
- 研究了CRHBP对中部前额皮层 (mPFC) 电路中的突触后活动的影响.
主要成果:
- 在雄性小鼠中发现oxtrINs调节与焦虑相关的行为.
- CRHBP是皮质激素释放激素 (CRH) 的抗体,其特异性表达在OxtrIN中.
- 在男性中,OxtrINs中的CRHBP产生抑制了CRH诱导的金字塔细胞活性的增强,从而产生抗焦虑作用.
结论:
- 对于调节两个性别的社会和情绪行为,OxtrINs至关重要.
- 在mPFC电路中,一个涉及OxtrINs中的CRHBP的分子机制协调了对催产素 (OXT) 和CRH的反应.
- 对OXT/OXTR和CRHBP/CRH途径的进一步研究对于开发针对性别的社会和情绪障碍疗法至关重要.
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