用于评估行动结果的基底腺回路
Marcus Stephenson-Jones1, Kai Yu1, Sandra Ahrens1
1Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.
Nature
|November 8, 2016
概括
在小鼠中评估行动结果时, habenula-projecting globus pallidus (GPh) 中的神经元至关重要. 这些基底腺回路整合相反的信号以确定结果是否超过或低于预期.
科学领域:
- 神经科学
- 决策研究
- 行为神经科学
背景情况:
- 基底腺对于决策,特别是行动选择至关重要.
- 基底回路在评估行动结果中的确切作用仍然不太清楚.
- 了解结果评估是解读复杂决策过程的关键.
研究的目的:
- 在评估行动结果时,研究 habecula-projecting globus pallidus (GPh) 的作用.
- 在结果评估中确定调节GPh功能的特定基底输入.
- 阐明GPh如何整合信息进行决策.
主要方法:
- 在老鼠中进行经典调节任务以评估结果评估.
- 对GPh神经元活动进行光遗传学操纵以模仿评估信号.
- 细胞类型特定的突触操纵以探测输入功能.
- 用狂犬病病毒辅助的单突触追踪来绘制GPh电路连接.
主要成果:
- 单个小鼠GPh神经元双向编码结果比预期更好或更差.
- 光遗传GPh刺激/抑制有效增强/抑制作用.
- 为了评估负面和积极的反,需要对GPh进行特定的抑制和刺激输入.
- GPh从条纹体 (两部分) 接收抑制输入,并从亚体核接收激发输入.
结论:
- GPh对于评估基底内作用的结果至关重要.
- 不同的基底腺回路为行动选择与结果评估提供信息.
- GPh集成相反的价值信息来指示结果的预期偏差.
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