抗体在结核病中的作用
Lenette L Lu1, Amy W Chung2, Tracy R Rosebrock3
1Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA; Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA.
Cell
|September 27, 2016
概括
结核病 (TB) 感染中的抗体显示出潜伏结核病感染和活跃结核病之间的不同模式. 这些抗体功能的差异,特别是Fc介导的效应器功能,可能在控制Mycobacterium结核病方面发挥关键作用.
科学领域:
- 免疫学
- 传染性疾病
- 微生物学
背景情况:
- 结核病 (TB) 仍然是一个全球性的健康挑战,因缺乏有效的诊断和疫苗而加剧.
- 在 Mycobacterium tuberculosis (Mtb) 感染中,幽默免疫,特别是抗体 (Abs) 的作用尚不清楚.
- 区分潜伏性结核病 (Ltb) 和活跃性结核病 (Atb) 对于疾病管理至关重要.
研究的目的:
- 在Ltb与Atb患者中研究独特的Mtb特异性幽默免疫反应.
- 在不同结核病感染状态下探索抗体的功能特征.
- 确定参与控制Mtb的潜在抗体介导机制.
主要方法:
- 用无偏见的抗体分析来分析Mtb特异性抗体反应.
- 评估了FcγRIII结合,抗体糖化模式和Fc效应器功能.
- 在Ltb和Atb个体的抗体存在的情况下,评估了细胞内Mtb的巨介导杀死.
主要成果:
- 在Ltb和Atb之间观察到不同的Mtb特异性抗体配置.
- 来自Ltb个体的抗体表现出独特的Fc功能特征和选择性的FcγRIII结合.
- 在Ltb和Atb之间发现了不同的抗体糖化模式.
- 与来自Atb的抗体相比,来自Ltb的抗体增强了酶体成熟,炎酶体激活和巨细胞介导的细胞内Mtb杀死.
结论:
- 幽默性免疫反应,特别是Fc介导的抗体效应器功能,在潜伏性结核病和活跃性结核病之间存在显著差异.
- 抗体糖化模式似乎调节了这些Fc介导的功能.
- 这些发现表明Fc介导的抗体效应器功能在控制Mtb感染方面可能发挥作用,为治疗策略提供了新的途径.
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