不同治疗干预措施中降低LDL-C和心血管风险降低之间的关联:系统审查和元分析
在PubMed上查看摘要
概括
此摘要是机器生成的。增加LDL受体表达的他类药物和非他类药物对降低LDL- C具有相似的心血管风险降低. 降低LDL- C水平与主要冠状动脉事件的减少有关.
科学领域
- 心血管医学
- 药理学
- 临床试验
背景情况
- 非他类药物治疗降低低密度脂蛋白胆固醇 (LDL- C) 的临床益处尚未完全了解.
- 评估各种降低LDL-C的策略的比较有效性对于心血管风险管理至关重要.
研究的目的
- 评估不同类他和非类他疗法的LDL-C降低与心血管风险之间的关联.
- 在随机临床试验中比较各种降低LDL- C的干预措施的疗效.
主要方法
- 在随机临床试验数据上进行了元回归分析.
- 包括的研究从1966年到2016年7月搜索了MEDLINE和EMBASE数据库.
- 分析了49项试验中的312,175名参与者的数据,重点是主要的血管事件.
主要成果
- 通过LDL受体上调作用的类他类药物和非类他类药物对每次LDL- C降低的重大血管事件具有相似的相对风险 (RR).
- 每降低1mmol/ L的LDL- C,主要血管事件的RR为0. 77对于他类药物和0. 75对于这些非他类药物.
- 在初级和二级预防中,较低的LDL- C水平与较低的冠状动脉事件发生率有显著的关联.
结论
- 通过降低LDL-C,降低心血管风险的效果相似.
- 达到较低的LDL- C水平始终与主要冠状动脉事件的发生率降低有关.
- 这些发现支持全面降低LDL- C的策略在预防心血管疾病中的作用.
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