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Updated: Jan 14, 2026

In Vivo CRISPR/Cas9 Screening to Simultaneously Evaluate Gene Function in Mouse Skin and Oral Cavity
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在单个树突脊柱内自性BDNF-TrkB信号传递

Stephen C Harward1, Nathan G Hedrick1, Charles E Hall1

  • 1Neurobiology Department, Duke University Medical Center, Research Drive, Durham, North Carolina 27710, USA.

Nature
|September 30, 2016
PubMed
概括

这项研究揭示了由大脑衍生的神经营养因子 (BDNF) 迅速从刺激的树突中释放出来,在局部激活其受体TrkB. 这种自克林信号对于神经元的结构和功能长期增强 (LTP) 是必不可少的.

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