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Updated: Mar 14, 2026

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在KRAS突变肺癌中,依赖XPO1的核出口是可用药物的弱点

Jimi Kim1, Elizabeth McMillan1, Hyun Seok Kim2

  • 1Department of Cell Biology, UTSW Medical Center, Dallas, Texas 75390, USA.

Nature
|September 30, 2016
PubMed
概括

针对KRAS突变肺癌的核出口是有前途的. 抑制XPO1 (出口因1) 提供了一种合成致死策略,在选定的患者中克服YAP1-TEAD抑制剂的抵抗.

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