成年人糖尿病患病率的种族差异可以通过肥胖的差异来解释吗?
T R O'Brien1, W D Flanders, P Decoufle
1Division of Chronic Disease Control, Centers for Disease Control, Atlanta, GA 30333.
JAMA
|September 15, 1989
概括
黑人被诊断患有糖尿病的患病率高于白人,即使考虑到肥胖. 这项研究表明,糖尿病的种族差异不仅仅是由于身体脂肪的差异.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 内部医学 内部医学
背景情况:
- 糖尿病是一种严重的公共卫生问题,在美国观察到存在种族差异.
- 肥胖是已知的糖尿病风险因素,种族群体之间的肥胖率差异可能导致糖尿病患病率的差异.
研究的目的:
- 调查肥胖的种族差异是否解释了美国黑人糖尿病的更高患病率.
- 为了检查被诊断为糖尿病和禁食高血糖症的患病率,黑人与白人美国陆军退伍军人,调整关键共变量.
主要方法:
- 一项对越南战争时期的美国陆军退伍军人的队列研究,包括12558名白人男性和1677名年龄在30-47岁之间的黑人男性.
- 诊断糖尿病的患病率被评估并根据肥胖,教育和收入进行调整.
- 在一个子组中测量了禁食血清葡萄糖值,以评估高血糖症 (≥7.8 mmol/L) 的患病率.
主要成果:
- 黑人男性被诊断为糖尿病的可能性明显高于白人男性 (调整后的患病率[aPR],1.9;95% CI,1.3至2.7).
- 在黑人男性中诊断出糖尿病的更高患病率在所有年龄,肥胖和社会经济层面都存在.
- 黑人男性患禁食高血糖症的可能性明显更高 (aPR,5.7;95% CI,2.7至12.0).
结论:
- 在黑人中诊断出糖尿病的更高患病率并不能由肥胖的种族差异来解释.
- 糖尿病患病率的种族差异明显,即使控制肥胖和社会经济因素.
- 需要进一步的研究来确定导致这些差异的潜在生物和环境因素.
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