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早期透镜提取治疗初级闭角眼 (EAGLE) 的有效性:随机对照试验
Augusto Azuara-Blanco1, Jennifer Burr2, Craig Ramsay3
1Centre for Public Health, Queen's University Belfast, Belfast, UK.
Lancet (London, England)
|October 7, 2016
概括
透明透镜抽取是一种比标准治疗更有效和更具成本效益的初始治疗方法,可降低眼内压力并改善患者的健康状况.
科学领域:
- 眼科 眼科
- 大眼的研究
- 进行手术
背景情况:
- 主要闭角眼 (PACG) 是全球不可逆转失明的重要原因.
- 早期的眼内压力升高 (IOP) 在没有初始视力损伤的情况下发生.
- 晶状透镜在PACG中发挥着关键作用,这表明透镜提取是潜在的早期治疗方法.
研究的目的:
- 将透明透镜提取与新诊断的PACG标准治疗的疗效和成本效益进行比较.
- 在36个月内评估患者报告的健康状况,眼内压力 (IOP) 和成本效益.
主要方法:
- 这是一项随机对照试验,涉及5个国家的30个眼科医院的50岁以上的419名新诊断的PACG患者.
- 患者被分配到透明透镜提取或标准治疗 (激光外周 iridotomy 和局部医疗治疗).
- 其他主要终点包括健康状况 (欧洲生活质量5个维度),内血压和经质量调整后每年增长的成本效益.
主要成果:
- 与标准治疗相比,透明透镜抽取导致平均健康状况得分显著改善 (高出0. 052),平均内血压下降 (1. 18毫米克).
- 透明透镜提取的增量成本效益比为每增加的质量调整寿命年14,284英.
- 一名患者出现视力损失 (透视镜抽取) 和三名患者出现视力损失 (标准治疗);没有报告严重的不良反应.
结论:
- 与初始PACG治疗的激光外皮切除术相比,透明透镜的提取显示出更高的疗效和成本效益.
- 对于患有初级闭角眼的患者来说,透镜抽取应被视为一种可行的第一线治疗选择.
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