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Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets
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有氧糖解通过表观遗传机制促进T助手1细胞的分化

Min Peng1, Na Yin1, Sagar Chhangawala2

  • 1Immunology Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY 10065, USA.

Science (New York, N.Y.)
|October 7, 2016
PubMed
概括

乳酸脱酶A (LDHA) 支持T细胞代谢,并通过表观遗传变化促进干扰素 (IFN-γ) 的产生. 抑制T细胞中的LDHA可以预防过度的IFN-γ驱动的炎症和自身免疫性疾病.

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