对寨卡病毒的DNA疫苗的快速开发
Kimberly A Dowd1, Sung-Youl Ko2, Kaitlyn M Morabito2
1Viral Pathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Science (New York, N.Y.)
|October 7, 2016
概括
一种表达寨卡病毒前膜和包膜蛋白的DNA疫苗显示出有前途. 在动物模型中,接种疫苗具有免疫性,对病毒性有保护性,这表明预防ZIKV感染的潜在策略.
科学领域:
- 病毒学
- 疫苗学
- 免疫学
背景情况:
- 寨卡病毒 (ZIKV) 从2015年开始在美洲和加勒比地区引起了重大先天性疾病爆发.
- 持续存在的胎风险需要采取预防措施,特别是在生育年龄的妇女及其伴侣身上.
研究的目的:
- 评估编码ZIKV前膜 (prM) 和包膜 (E) 蛋白质的DNA疫苗的免疫性和保护性.
- 确定疫苗诱导的中和活性与对ZIKV病毒病的保护是否相关.
主要方法:
- 开发了一种表达ZIKV prM和E蛋白质的DNA疫苗.
- 在小鼠和非人类灵长类动物中评估疫苗的免疫性.
- 用ZIKV接种疫苗的受试动物,以评估对病毒病的保护.
主要成果:
- 在小鼠和非人类灵长类动物中,DNA疫苗具有免疫性.
- 接种疫苗可以预防ZIKV感染后的病毒病.
- 疫苗接种后的血清中和活性与对病毒病的保护相关.
结论:
- 针对ZIKV prM和E蛋白的DNA疫苗是预防ZIKV感染的一种可行的方法.
- 建议为疫苗诱导的中和活性设置一个保护值,该值能够防止急性感染后的病毒血症.
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