链接素H1.0产生了表观遗传和功能性瘤内异质性
Cristina Morales Torres1, Alva Biran2, Matthew J Burney1
1Cancer Epigenetics Laboratory, The Francis Crick Institute, Lincoln's Inn Fields Laboratory, London WC2A 3LY, UK.
Science (New York, N.Y.)
|October 7, 2016
概括
动态表观遗传状态,标志着链接组合素H1.0,决定了长期的癌症生长. H1.0水平与瘤特征和癌症干细胞标志物相关,揭示了瘤维持细胞的关键表观遗传调节剂.
科学领域:
- 表观遗传学
- 癌症生物学
- 细胞异质性
背景情况:
- 瘤含有不同的细胞亚群,具有不同的增殖能力.
- 表观遗传修饰在调节细胞行为和瘤进展方面起着至关重要的作用.
研究的目的:
- 调查动态表观遗传状态的作用,特别是链接组合素H1.0,以确定维持瘤的细胞.
- 了解H1.0水平如何影响癌细胞的自我更新,分化和长期生长.
主要方法:
- 对各种癌症类型的H1.0异质性的分析.
- H1. 0水平与瘤分化,患者存活率和癌症干细胞标志物的相关性.
- 研究H1.0沉默和再表达对癌细胞增殖和分化的功能后果.
主要成果:
- 在许多癌症类型中观察到H1. 0的高瘤内部和瘤内部异质性.
- H1. 0水平与瘤分化状态,患者存活率和癌症干细胞标志物相关.
- 通过消除致癌途径因子,H1.0沉默促进了自我更新,而H1.0再表达则限制了扩散和诱导的分化.
结论:
- 通过链接基因素H1.0定义的动态表观遗传状态是维持瘤细胞的关键决定因素.
- H1.0作为癌细胞可塑性的关键调节剂,控制自我更新和分化之间的平衡.
- 针对H1.0表观遗传状态可能为癌症治疗提供新的治疗策略.
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