宿主-原生菌相互作用 通过激活炎症体,防止粘膜感染
Aleksey Chudnovskiy1, Arthur Mortha1, Veronika Kana1
1Department of Oncological Science, Icahn School of Medicine at Mount Sinai, 1475 Madison Avenue, New York, NY 10028, USA; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, 1475 Madison Avenue, New York, NY 10028, USA; The Immunological Institute, Icahn School of Medicine at Mount Sinai, 1475 Madison Avenue, New York, NY 10028, USA.
Cell
|October 8, 2016
概括
原生动物Tritrichomonas musculis通过激活炎症体和诱导IL-18增强了对细菌感染的粘膜免疫. 然而,它也增加了诸如结肠炎和结直肠瘤等炎症性疾病的风险.
科学领域:
- 微生物学
- 免疫学
- 胃肠病学
背景情况:
- 脊椎动物微生物组包括一个鲜为人知的构成性原生菌群.
- 这些原生体在宿主免疫和粘膜平衡中的作用在很大程度上尚未研究.
研究的目的:
- 研究原生Tritrichomonas musculis对宿主粘膜免疫力的影响.
- 探索T. musculis影响宿主防御和疾病发展的机制.
主要方法:
- 使用T. musculis殖民模式的体内研究.
- 炎酶激活和细胞因子释放的分析 (IL-18).
- 评估T细胞反应 (Th1,Th17) 和对细菌感染和炎症疾病的敏感性.
主要成果:
- T. 肌肉激活宿主上皮炎酶,导致IL-18的释放.
- 皮质衍生IL-18促进Th1和Th17免疫力,提供对粘膜细菌感染的保护.
- T. musculis殖民导致T细胞驱动的大肠炎和结肠直肠瘤发生.
结论:
- 肌肉性T.参与相互作用,增强粘膜防御.
- 这种相互作用的代价是增加对炎症状况的敏感性.
- 这些发现突出了原生体在宿主微生物组动态和免疫调节中的新角色.
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