视觉皮层的皮层-流体输出促进了先天的运动行为可塑性
Bao-Hua Liu1,2, Andrew D Huberman3, Massimo Scanziani1,2,4
1Howard Hughes Medical Institute and Center for Neural Circuits and Behavior, University of California San Diego, La Jolla, California 92093-0634, USA.
Nature
|October 13, 2016
概括
视觉皮层通过向大脑干投射来影响天生的运动行为,例如光运动反射 (OKR). 这些预测对于调整OKR至关重要.
科学领域:
- 神经科学
- 视觉系统
- 发动机控制
背景情况:
- 哺乳动物的视觉皮层通过皮层-流体投射连接到大脑干,影响先天的运动行为.
- 由大脑干辅助光学系统介导的光动力反射 (OKR) 稳定视网膜图像,对视力至关重要.
- OKR可塑性允许终身视觉稳定性,可能涉及皮层下和皮层结构.
研究的目的:
- 研究视觉皮层向大脑干投射的作用,以调解光动力反射的适应性可塑性 (OKR).
主要方法:
- 在小鼠中对辅助光学系统的视觉皮层投射的沉默.
- 针对向辅助光学系统投射的特定皮质-神经元的切除.
- 在前庭功能障碍后评估光动力反射 (OKR) 强化.
主要成果:
- 沉默视觉皮层减少了OKR的强化, 这表明视觉皮层在这个适应过程中的作用.
- 切除向辅助光学系统投射的特定皮质-神经元严重损害了OKR强化.
- OKR增强与视觉皮层对辅助光学系统的增强影响有关.
结论:
- 从视觉皮层到脑干的皮层-流体投射对于光运动反射的适应性可塑性至关重要.
- 视觉皮层积极调节天生的运动行为, 扩展其已知的功能超越感官处理.
- 这项研究突出了视觉皮层在整个生命中保持视觉稳定的新机制.
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