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Updated: Mar 13, 2026

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
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破裂诱导的端粒合成是替代端粒维持的基础

Robert L Dilley1, Priyanka Verma1, Nam Woo Cho1

  • 1Department of Cancer Biology, Abramson Family Cancer Research Institute, Basser Research Center for BRCA, Perelman School of Medicine, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA.

Nature
|November 4, 2016
PubMed
概括

癌症中的替代端粒延长 (ALT) 依赖于同质导向的DNA修复. 这项研究揭示了一种特殊的破裂诱导的复制体,使得DNA损伤后的端粒合成成为可能,这对ALT维持至关重要.

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