疟疾:生物学与疾病
Alan F Cowman1, Julie Healer2, Danushka Marapana1
1Walter and Eliza Hall Institute of Medical Research, Melbourne 3051, Australia; Department of Medical Biology, University of Melbourne, Melbourne 3052, Australia.
Cell
|October 22, 2016
概括
在控制疟疾方面取得了显著进展, 新的抗疟疾药物和疫苗对于实现这一目标至关重要.
科学领域:
- 全球健康
- 传染性疾病
- 寄生虫学
背景情况:
- 疟疾仍然是一个重大的全球卫生负担,特别是在热带和亚热带地区.
- 在过去的15年里, 最近的防治工作成功地将疟疾的流行率降低了50%以上.
- 消除和根除疟疾的前景现在是一个切实可行的长期可能性.
研究的目的:
- 突出疟疾控制方面的进展以及对创新工具的持续需求.
- 强调新型抗疟疾药物和疫苗在消除疾病方面的重要性.
- 强调我们需要进一步了解疟疾的生物学和寄生虫.
主要方法:
- 审查疟疾控制战略的最新进展.
- 对新型抗疟疾干预措施的开发管道的分析.
- 检查研究工作的重点是寄生虫生物学和疾病机制.
主要成果:
- 第一个疟疾疫苗 (RTS,S/AS01) 已获得监管部门的批准.
- 已经确定了新的药物标和抗疟疾化合物.
- 目前有几种新的抗疟疾药物正在人类临床试验中.
结论:
- 持续开发新型抗疟疾药物和疫苗对于消除疟疾至关重要.
- 对疟疾寄生虫生物学有更深入的了解对于未来的控制工作至关重要.
- 最近的突破为长期根除疟疾提供了重大希望.
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