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超低功率近红外灯光可操作的有机纳米粒子光动力疗法

Ling Huang^1,2, Zhanjun Li¹, Yang Zhao^1,3

¹Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School , Worcester, Massachusetts 01605, United States.

Journal of the American Chemical Society

|October 28, 2016

概括

这项研究引入了用于光动力学治疗 (PDT) 的新近红外吸收纳米粒子. 这些生物相容纳米粒子有效地利用低功率光对深层组织瘤进行向, 为癌症治疗提供了一个新的平台.

科学领域:

生物医学工程
材料科学
摄影化学

背景情况:

光动力疗法 (PDT) 面临着组织透深度的挑战.
开发用于深层组织治疗的有效光敏剂至关重要.

研究的目的:

为PDT开发可图像导向,可激活深层组织的光敏感剂.
为增强瘤向和治疗创造生物相容,近红外 (NIR) 光吸收的有机纳米粒子.

主要方法:

合成了一种具有强烈NIR吸收的碳醇替代BODIPY (Car-BDP) 分子.
将Car-BDP封装成可生物降解的PLA-PEG-FA聚合物,形成水溶性的瘤向纳米颗粒.
使用低功率灯光评估光动力疗效,并通过NIR光追踪进行体内评估.

主要成果:

汽车BDP表现出强烈的,广泛的NIR吸收 (600-800 nm) 和高单片氧量子产量 (ΦΔ = 67%).
封装的纳米颗粒显示出均的大小,水溶性和瘤向能力.
通过低功率灯光 (12 mW cm-2) 实现了显著的深层组织光动力疗效.
在体内成功追踪纳米粒子使用它们的NIR光.

结论:

开发了一种新的NIR吸收生物相容的有机纳米粒子,用于有效的深层组织瘤向和治疗.
开发的纳米粒子为精确的瘤向术提供了一个有前途的平台.
通过使用新型PDT方法提供了负担得起的临床癌症治疗机会.

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