在炎症的肠道中,微素调解肠道细菌之间的竞争
Martina Sassone-Corsi1,2, Sean-Paul Nuccio1,2, Henry Liu1
1Department of Microbiology and Molecular Genetics, University of California Irvine, Irvine, California 92697, USA.
Nature
|November 8, 2016
概括
由益生菌 Escherichia coli Nissle 1917 (EcN) 生产的微蛋白限制了炎症肠道中的竞争细菌的生长. 这项研究表明微蛋白可以通过抑制沙门氏菌等病原体来治疗肠道炎症.
科学领域:
- 微生物学
- 细菌学
- 肠道微生物组研究
背景情况:
- 肠道细菌是导致全球显著发病率和死亡率的グラム阴性细菌.
- 肠道中肠杆菌的扩张,称为失生症,与肠道炎症有关.
- 小微生物蛋白的体内作用在肠道竞争中以前是不清楚的.
研究的目的:
- 研究微蛋白在炎症肠道内的细菌竞争中的作用.
- 确定大肠杆菌Nissle 1917 (EcN) 产生的微蛋白是否可以在肠道炎症期间限制肠杆菌的扩张.
- 评估微蛋白对肠道病原体的治疗潜力.
主要方法:
- 使用益生菌大肠杆菌尼斯尔1917 (EcN) 作为微信生产剂.
- 在肠道炎症和沙门氏菌感染的小鼠模型中使用野生类型的产生微素的EcN.
- 监测竞争性肠杆菌的生长,包括开始性大肠杆菌,附着性侵袭性大肠杆菌和沙门氏菌.
主要成果:
- 在炎症的肠道中,产生微信的EcN有效地限制了竞争性肠道细菌的扩散.
- 在感染的小鼠中,治疗用产生微素的EcN显著减少了Salmonella enterica的肠道定居.
- 证明微在炎症的肠道中调解了 Enterobacteriaceae 之间的相互和内部竞争.
结论:
- 微蛋白对于益生菌大肠杆菌Nissle 1917在肠道炎症期间控制竞争性肠杆菌至关重要.
- 微可以作为狭窄光谱的治疗药物来抑制肠道病原体和控制失调.
- 这项研究为肠道中介细菌竞争提供了第一个体内证据.
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