脂肪酸合成对糖尿病患者的炎症进行配置
Xiaochao Wei1, Haowei Song1, Li Yin1
1Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Nature
|November 5, 2016
概括
巨脂肪酸合成酶 (FAS) 对于饮食引起的胰岛素抵抗和炎症至关重要. 通过改变膜组成和信号通路,抑制巨细胞中的FAS可以预防这些情况.
科学领域:
- 免疫学
- 代谢疾病
- 细胞生物学
背景情况:
- 饮食中的脂肪会通过慢性炎症引发胰岛素抵抗.
- 大细胞衍生的炎症蛋白质会影响这一过程.
- 营养丰富饮食在糖尿病发病中的作用尚不清楚.
研究的目的:
- 研究巨细胞内源性脂肪酸合成在饮食引起的胰岛素抵抗中的作用.
- 确定巨脂肪酸合成酶 (FAS) 对炎症和代谢功能障碍的影响.
主要方法:
- 使用Fasn基因被删除的小鼠.
- 膜组成,胆固醇保留和Rho GTPase流通的分析.
- 对炎症信号和胰岛素抵抗的评估.
主要成果:
- 预防饮食引起的胰岛素耐药性,脂肪组织炎症和巨细胞招募.
- FAS缺乏改变了膜秩序和胆固醇保留,扰乱了Rho GTPase的运输.
- 外源胆固醇,但不是棕酸盐, 挽救了炎症信号.
结论:
- 巨细胞内源性脂肪酸的产生对于由食脂肪引起的胰岛素耐药性发展至关重要.
- 在巨细胞中,FASN形成了有利于胆固醇依赖的信号网络的血膜环境,从而导致炎症.
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