影响个体细胞因子反应的宿主和环境因素
Rob Ter Horst1, Martin Jaeger1, Sanne P Smeekens1
1Department of Internal Medicine and Radboudumc Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Gelderland 6500HB, the Netherlands.
Cell
|November 5, 2016
概括
环境因素如年龄,性别和季节性显著影响人体免疫反应,影响细胞因子的产生. 阿尔法-1抗素水平部分解释了季节性免疫变化,而维生素D
科学领域:
- 人类功能基因组学
- 免疫学
- 环境健康
背景情况:
- 免疫媒介疾病是由于免疫反应的变化引起的.
- 了解影响人类免疫变化的因素至关重要.
研究的目的:
- 研究非遗传宿主因素和环境影响对人类细胞因子反应的影响.
- 分析这些因素,循环介质和细胞因子产生之间的关联.
主要方法:
- 在534名健康受试者中分析细胞因子的产生和循环介质.
- 用19种不同的微生物和非微生物激活.
- 评估环境因素 (季节性,年龄,性别) 和宿主遗传.
主要成果:
- 年龄和性别等非遗传因素强烈影响细胞因子的产生和调解剂水平.
- 每年的季节性是影响细胞因子反应的重要环境因素.
- 阿尔法-1抗素部分调节季节性;维生素D的影响有限.
结论:
- 非遗传宿主因素和环境季节性是人类免疫反应变化的关键决定因素.
- 季节性对免疫媒介的影响部分由α-1-抗素解释.
- 公开的数据为未来的免疫学研究提供了资源.
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