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神经调节器通过星球细胞发出信号,改变神经电路活动和行为

Zhiguo Ma¹, Tobias Stork¹, Dwight E Bergles²

¹Department of Neurobiology and Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.

|November 10, 2016

概括

德洛索菲拉星细胞通过八胺/提拉胺受体和水魔女通道通过 (Ca2+) 向神经元发出信号. 这种天体细胞信号调节神经传递,对于化学反应等感官行为至关重要.

科学领域:

神经科学是一个神经科学.
细胞生物学细胞生物学
神经生物学神经生物学神经生物学

背景情况:

星球细胞是大脑功能中不可或缺的质细胞,与突触相互作用并响应神经递质.
星细胞 (Ca2+) 信号与调节神经回路有关,但调节途径和体内证据有限.
了解神经细胞-神经元通信对于破译神经电路活动和行为至关重要.

研究的目的:

在体内研究Drosophila天体细胞中活动调节的 (Ca2+) 信号传递.
为了确定特定的分子通路和受体参与天体细胞Ca2+对神经元活动的反应.
确定天体细胞Ca2+信号在调节神经传递和感官驱动行为中的作用.

主要方法:

使用Drosophila melanogaster作为体内研究的模型生物.
研究神经元向星球细胞发送信号,使用胺和胺.
检查了八胺/胺受体 (Oct-TyrR) 和短暂受体潜力 (TRP) 通道水魔女 (Wtrw) 在天体细胞Ca2+信号传递中的作用.
评估了天体细胞Ca2+信号对多巴胺基神经元活动的影响.
在天体细胞通路的基因操纵后,分析了行为变化 (嗅觉化学反应,触觉诱发的惊).

主要成果:

德洛索菲拉星球细胞在体内表现出活动调节的Ca2+信号.
提拉胺和八胺直接通过Oct-TyrR和Wtrw刺激星细胞Ca2+的增加.
通过内细胞功能和腺素受体介导的星细胞Ca2+信号传递抑制了多巴胺基神经元活动.
星球细胞中Oct-TyrR或Wtrw的干扰取消了Ca2+信号传递和受损的嗅觉化学反应和触摸诱导的惊反应.

结论:

确定了Oct-TyrR和Wtrw作为天体细胞Ca2+信号机制的关键组件.
提供了直接证据,证明天体细胞参与了由八胺和胺介导的神经调节.
证明了星体细胞在调节多种感官驱动行为中的重要作用.

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